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KMID : 0376219640010020167
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Chonnam Medical Journal
1964 Volume.1 No. 2 p.167 ~ p.177
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Modification of Drug Actions on the Ciliary Activity by Varying Ion Concentrations
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Abstract
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It is shown in this paper that slight modifications of composition of Ringer´s solution (ATP added) affected markedly the ciliary activity of the frog´s esophagus and its response to drugs.
1) CaCl₂when its concentration was raised to 2-8 times of the original one (0.12g/l), accelerated significantly the speed of the transit of the poppy seeds. Increase of KCI(2-fold of the original concentration, 0.1㎍/1)depressed the activity;decrease of KCI(to 1/4 of the original)accelerated it. Either increase or decrease of NaCl content by 50% slowed down the ciliary movement. Removing of CaCl₂from Ringer´s solution inhibited the movement but onset of the effect was delayed. 2) MgCl₂(0.24-0.56g/1)accelerated the ciliar activity. 3 Acetylcholine and succinylcholine demonstrated different effects with varying doses; 100㎍/ml of acetylcholine and 5-1C㎍/ml fo succinylcholine caused inhibition, 500㎍/ml of acetylcholine and 50㎍/ml of succinylcholine stimulation. 5-Hydroxytryptamine (100㎍/ml)accelerated the activity. The accelerating effect of these substances was not observed when Ringer´s solution containing double amount of CaCl₂was employed. 4) The prominent slowing effect of tubocurarine, flaxedil, decamethonium, tetracaine and scopolamine was not demonstrated when Ringer´s solution contained double amount of CaCl₂. When the ciliary activity was depressed by doubling KCI in Ringer´s solution, the above substances did not cause further depression, except tetracaine and scopolamine, which still evoked more slowing. 5) The marked accelerating effect of aconitine was affected by increase of either CaCl₂or KCI. The change of the concentration of NaCl also aboished its accelerating effect.
The above results strongly suggest that the experimental results on the ciliary movement are varied by differenced of composition of Ringer´s solution employed. The discrepancies reported of the effects of acetylcholine or tubocurarine (Kordiket al., 1952;and Day, 1958; Hill, 1957)may be attributable to the composition of solutions employed by them.
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